Posted by yxibow on October 28, 2006, at 21:32:40
In reply to No longer sedated by 300mg seroquel, posted by Lindenblüte on October 28, 2006, at 16:40:49
> Hi all,
> About a month ago, my pdoc increased my seroquel dose from 50 mg titrating up to 300mg. Reason- to reduce intrusive thoughts of bad stuff, flashbacks, etc. I protested, saying I'd be a zombie. My pdoc said I'd get used to it. pdoc was right. I can't believe it.
> I take it at night. Within 20-30 minutes, I'm barely able to stagger to bed. Then I sleep for 8-9 hours and I wake up and feel fine. It took about a week once I got to the 300mg dose before the fatigue went away. For the first week, I could barely manage to swallow a provigil pill before collapsing in bed and getting up an hour later to make a big pot of coffee.
> Fatigue did go away though. So did most of my bad thoughts and flashbacks. (I'm not psychotic, btw)
> Here are my other meds.
> 120mg cymbalta, 200mg provigil, klonopin prn.
> If your doctor asks you to take a dose of seroquel, and you find it completely knocks you out, try titrating up gradually. It took me 10 days to go from 50-300.
Same with doxepin. Which I took instead of Trazodone over the weekend at college. It destroyed that weekend and I never went back to it. So I suffered the occasional minor priapism. But Trazodone is yucky anyhow, glad I don't have that on my off label plate...
> Don't give up- I hope you will be able to stick it out for a week at your final therapeutic dose and see if the fatigue/sedation gets better each day. This morning I was feeling so awake, I forgot to take my provigil until I had been up for an hour already :)
Glad things are working out with the Seroquel -- the modafinil is probably moderating it. I know at 800 mg, I stagger out of bed still. If I take it too late, i.e. stay up, like 1 or 2 am, it takes 2 half lives (12 hours) before I'm not completely free from its grasp, which means not until 2 in the afternoon. If I have to be somewhere early, I try (hard to resist staying up sometimes) to take it at 10-11, or at least midnight.