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Re: Stelazine with a topping of razadyne

Posted by river1924 on October 28, 2006, at 19:20:31

In reply to Re: Stelazine with a topping of razadyne » river1924, posted by ed_uk on October 22, 2006, at 7:13:24

HI Ed, I ran across this article when I was trying to figure out something about epigenetics and it may (if I understand the lingo) explain some of the benefits I get from razadyne.

The nicotinic cholinergic system has been widely implicated in mediating learning and/or memory processes in human and nonhuman animals. This chapter highlights various areas of basic research in which stimulation or blockade of nicotinic acetylcholine receptors (nAChRs) has been shown to affect an animal’s performance in a variety of tasks thought to measure learning and memory. For example, under certain conditions, stimulation of nAChRs by nicotine (or other nAChRs agonists) can enhance working memory of primates as measured in a delayed matching-to-sample task. Attentional processes are also improved in rats as indexed by a five-choice serial reaction time task. Further, recent research suggests that stimulation of nAChRs by nicotine likely enhances the incentive salience of stimuli. We elaborate on a model by which this enhancement might occur and suggest that the role of this incentive mechanism in relation to learning and memory processes requires more empirical attention. Finally, there appears to be overlap in the processes by which nAChRs affect learning and memory. That is, enhanced incentive salience might be responsible for the increased attentional effects of nicotine, or vice versa. Subsequent research needs to refine the behavioral techniques so as better dissociate, if required, these mechanisms.




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