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Anxiety: Norepinephrine vs. Glutimate

Posted by sregan on October 27, 2006, at 22:00:43

I've suffered from a depression/anxiety for about 3 years and recently tried TCAs amitriptyline and imipramine. The palpatations and rush I feel from the excess NE is much different than my anxiety which does respond to Klonopin and Xanax.

I've read of anxiety happening in the case of low or high NE, low serotonin or high dopamine. But how do the Glutimate receptors factor in? My understanding is that the GABA/Glutmate receptors act as a volume switch of sorts. Stimulate Glutimate or block GABA and the volume goes way up. The opposite the volume goes down. But does the stimulation of the Glutimate receptor itself cause a "flavor" of anxiety?

It's a shame we don't have a better vocabulary to describe symptoms. We have no way to express variations in our similar symptoms. I definitely experienced a different type of anxiety on the TCAs because of the high NE than I've experienced in the past.

Does anyone have any experiences or ideas on what different flavors of anxiety there are? Sometimes I read descriptions that you just know something is very wrong like you are dying (outside the high NE side effects that might scare someone) just an inner feeling that this isn't going to end well.


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poster:sregan thread:698319
URL: http://www.dr-bob.org/babble/20061020/msgs/698319.html