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Re: Best pick-me-up: 10mg Parnate or cup of coffe » Lindenblüte

Posted by Don_Bristol on October 15, 2006, at 20:42:38

In reply to Re: Best pick-me-up: 10mg Parnate or cup of coffe » Don_Bristol, posted by Lindenblüte on October 15, 2006, at 19:13:40

> I find provigil to be a very effective stimulant- there
> was one memorable night when I accidentally took it
> with my evening meds. oopsie! Keeping in mind that one
> of my evening meds at the time was 50mg of seroquel,
> provigil kept me up ALL night long. of course, by
> about 11am the next day, I was kinda zonked, but you
> know...
> -Li

I get that if I take my last daily dose of 20 mg Parnate after about 7 or 8 pm. After that staying up all night is easy. And I can usualy keep going until 5pm before I get an hour or so of sleep.

You said you were zonked after a night up with provigil. I recall an early report in "THE ECONOMIST" about Provigil/Modafinil. This is from their Dec 19th 2002 edition. However your experience may not support thie propoposition. OTOH maybe you were zonked from something else you were taking like the Seroquel. I would be interested to know.

--------------- START QUOTE: ECONOMIST on PROVIGIL ----------
It is a treatment for narcolepsy (which makes sufferers irresistibly sleepy during the day) that has got the sleep scientists really excited. A few years ago, America's Food and Drug Administration approved a drug called Modafinil, sold under the brand name Provigil, to combat daytime sleepiness in narcoleptics. Modafinil makes up for patients' deficiency in a neurotransmitter called orexin, though no one knows quite how.

What is clear, however, is that the drug can also keep awake people who are tired for other reasons. That in itself is nothing new: coffee and amphetamines have a similar effect. But Modafinil's special attraction is that it does not seem to produce a “rebound” effect, whereby sleep eventually catches up after a prolonged period of wakefulness. The drug seems capable of keeping people alert for several days and nights without apparently building up any kind of sleep debt. “Half the people at sleep meetings are already taking it,” says Dr Williams.

For those who feel that life is far too short to spend a third of it asleep, this sounds like the Holy Grail. Just imagine: soldiers who can keep fighting for days until the battle is won; pilots who can fly around the world in one go; doctors who can perform marathon life-saving operations. And why stop there? Night-shift workers need never nod off again; managers can work non-stop to finish that vital report and still be perky to present it in the morning; and politicians can campaign without ever dropping. Or can they?

So far, the drug is licensed only for the treatment of narcolepsy. Experts are cautious, saying it is early days and much more investigation is needed. It may well be that Modafinil, like other drugs, proves a useful addition to the sleep scientists' toolkit. But it would be very astonishing if we could eliminate sleep altogether simply by popping a pill. If we do not even know why humans, along with all other higher animals, need to sleep, how can we be sure it is safe to stop doing so?
--------------- END QUOTE: ECONOMIST on PROVIGIL ----------

Best wishes




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