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Re: OCD as an example

Posted by alexandra_k on October 13, 2006, at 1:17:54

In reply to Re: OCD as an example alexandra_k, posted by Squiggles on October 11, 2006, at 8:14:44

> I think this article is an exception to the rule.

Anxiety and depression (the two most prevalent disorders) seem to be similarly exceptions:

fMRI predictors of treatment outcome in pediatric anxiety disorders.

McClure EB, Adler A, Monk CS, Cameron J, Smith S, Nelson EE, Leibenluft E, Ernst M, Pine DS.

Department of Psychology, Georgia State University, P.O. Box 5010, Atlanta, GA, 30302-5010, USA, emcclure@gsu.edu.

INTRODUCTION: A growing number of studies have found evidence that anxiety and depressive disorders are associated with atypical amygdala hyperactivation, which decreases with effective treatment. Interest has emerged in this phenomenon as a possible biological marker for individuals who are likely to benefit from tailored treatment approaches.

OBJECTIVE: The present study was designed to examine relationships between pretreatment amygdala activity and treatment response in a sample of anxious children and adolescents.

MATERIALS AND METHODS: Participants, who were diagnosed predominantly with generalized anxiety disorder (GAD), underwent functional magnetic resonance imaging (fMRI) scanning before treatment with fluoxetine or cognitive behavioral therapy (CBT).

RESULTS: Results indicated significant negative associations between degree of left amygdala activation and measures of posttreatment symptom improvement in the group, as a whole.

DISCUSSION: Taken together with research on associations between adult amygdala activation and treatment response, these findings suggest that patients whose pretreatment amygdala activity is the strongest may be particularly likely to respond well to such widely used treatments as selective serotonin reuptake inhibitor (SSRI) medications and CBT.

PMID: 16972100 [PubMed - as supplied by publisher]

So that is three disorders. The three that are... Most prevalent. I'm fairly sure that depression, anxiety, and OCD are the most prevalent disorders...

> It takes some pretty strong brain-washing methods to change brain states through therapy.

That is an empirical matter. Precisely what works in therapy is still open just like precisely what works in medication is still open...

> try therapy on a
> manic in the middle of extreme anxiety and agitation and i'll bet you that a benzo is worth one thousand kind words.

So you derive your rule from your disorder. I thought we were talking about mental illness more generally...

There isn't much on CBT with bi-polar and symptoms of schizophrenia. Though researchers have been turning to symptoms of schizophrenia i imagine bi-polar research won't be too far away. i'm not saying that medication is hopeless, remember. Just saying that therapy tends to be undervalued (that is to say undervalued considering the findings of its effectiveness).

 

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poster:alexandra_k thread:693568
URL: http://www.dr-bob.org/babble/20061011/msgs/694388.html