Posted by psychobot5000 on October 3, 2006, at 14:55:09
In reply to Re: Antihistamine, posted by SLS on October 3, 2006, at 11:04:16
Doxepin/Sinequan is actually the most effective antihistamine known to man. The reason it's not used much is because of all the tricyclic side-effects. For example, you can only smear the ointment on so much of your body, before you must worry about absorbing too much internally, and getting tachycardia (from antimuscarinic effects) and heavy sedation.
Also, it has the commercial disadvantage of being old and cheap.
As for Remeron, I don't think clinicians and researchers consider it as powerful an antihistamine as some others (I have read words to this effect), despite the powerful sedative and appetite stimulant effects that indicate otherwise. ...But it also has more side-effects than, say, benadryl.
But seriously, if you have a rash (that's doesn't cover too much body area), doxepin/sinequan is the strongest and best remedy.
P-bot
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> Remeron is used to treat pruritis, from what I could gather doing a Google search. However, I have often wondered the same thing you have about drugs like Remeron and Sinequan. What is it about them that has prevented them from becoming known as effective antihistamines? I haven't looked into their differential pharmacology. Maybe there are subtypes of the H1 receptor. I don't really know.
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> - Scott
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poster:psychobot5000
thread:691471
URL: http://www.dr-bob.org/babble/20061003/msgs/691524.html