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Fluvoxamine for delusional depression

Posted by flip-floppy on September 18, 2006, at 5:42:11

In reply to psychosis and AP substitutes, posted by nellie7 on September 12, 2006, at 14:40:27

Fluvoxamine alone in the treatment of delusional depression

F Gatti, L Bellini, M Gasperini, J Perez, R Zanardi and E Smeraldi
Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, Italy.

OBJECTIVE: The aim of this study was to evaluate the efficacy of fluvoxamine in the treatment of delusional depression. METHOD: Fifty- nine inpatients who met the DSM-III-R criteria for major depression with psychotic features were treated with fluvoxamine for 6 weeks. Patients were assessed at baseline and weekly thereafter with the Hamilton Depression Rating Scale and the Dimensions of Delusional Experience rating scale. RESULTS: Of the 57 subjects completed the trial, 84.2% (N=48) recovered. The index episodes of the patients who did not respond to fluvoxamine were of significantly longer duration than those of the responders. CONCLUSIONS: Fluvoxamine has a response rate similar to that of the currently most efficacious treatments for delusional depression, including antidepressants plus antipsychotics and ECT.


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