Posted by SLS on September 17, 2006, at 11:48:53
In reply to Re: Tonight I don't feel that antidepressants work, posted by SLS on September 17, 2006, at 10:18:09
> I'll be the optimist.
>
> In clinical trials: With any single antidepressant, 65-70% improve with greater than a 50% reduction in rating scale scores. 35-40% achieve remission at 6 weeks. Again, this represents the likelihood that someone will respond to that specific antidepressant if tried.
>
> Now, the thing is, these trials stop at 6 weeks. What if the 50% reduction responders were evaluated at 6 months? How many of them would go on to full remission? Hmm.
>
> Placebo comes in at 25-30% Even though placebo usually comes in with statistically lower numbers than antidepressants, the rate is, in my opinion, too high for reasons that I have discussed along other threads. They involve selection criteria and the allowance of subjects who I do not believe meet the criteria for a properly diagnosed Major Depressive Disorder (MDD). Now. The thing is, these studies stop at 6 weeks. Placebo pattern responders, as identified by Quitkin et al., have been shown to relapse more frequently than true drug responders. They, too, are not followed beyond 6 weeks.The rest of us come here.
:-(
And get better using other drugs and drug combinations, and CBT, and supplements, and all sorts of other stuff!
:-)
- Scott
poster:SLS
thread:686696
URL: http://www.dr-bob.org/babble/20060909/msgs/686800.html