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Dexamethasone effect on cortisol???Raise/lower?

Posted by Jimmyboy on September 11, 2006, at 17:36:04

Anyone know if taking dexamethasone raises or lowers your cortisol level? Read this and can't figure it out , maybe someone else can..
From : http://www.psychosomaticmedicine.org/cgi/content/full/61/5/698

"If short-term, high-dose dexamethasone treatment proves to have antidepressant effects, how might this be reconciled with antiglucocorticoids having similar effects? Antiglucocorticoids and dexamethasone administration could both have antidepressant effects via 1) their common effect of lowering cortisol levels (with resultant upregulation of brain corticosteroid receptors); 2) altering levels of other adrenal steroid hormones; or 3) increasing ACTH levels (with short-term, high-dose dexamethasone treatment, this might occur after dexamethasone’s acute inhibitory effects are terminated and the suppressed adrenal axis signals increased ACTH output). Additionally, recent evidence suggests that dexamethasone is actively excluded from brain and does not replace endogenous corticosteroids at hippocampal mineralocorticoid and glucocorticoid receptor sites (144). Its behavioral effects, therefore, may result from indirect effects of dexamethasone-induced ACTH suppression on the balance between the two corticosteroid receptor types in the hippocampus (144). Long-term dexamethasone treatment has also been shown to result in an increase in glucocorticoid receptor mRNA levels in hippocampus, an effect that parallels changes observed over the course of antidepressant treatment (33, 145). "


JB


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poster:Jimmyboy thread:685086
URL: http://www.dr-bob.org/babble/20060909/msgs/685086.html