Posted by linkadge on August 31, 2006, at 16:25:41
I read this from an article, read the whole article for context. Its about mice lacking MAO-A, or MAO-B.
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http://www.eurekalert.org/pub_releases/2004-09/asfb-smp090704.php
"Looking further into the matter, Dr. Shih determined that a spontaneous mutation in a single nucleic acid base pair in the MAO A gene created a premature stop which prevented it from being made into a protein. The scientists hypothesize that the mutation was due to elevated levels of the MAO B substrate phenylethylamine in the MAO B knockout mice. Phenylethylamine is a neuromodulator which, when broken down into its metabolites, has been shown to cause mutations in DNA. "
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Does this mean that elevating PEA with a MAO-B inhibitor could be neurotoxic ?Linkadge
poster:linkadge
thread:681773
URL: http://www.dr-bob.org/babble/20060825/msgs/681773.html