Posted by Tomatheus on August 25, 2006, at 22:18:58
In reply to Re: Which MAOI?, posted by psychobot5000 on August 18, 2006, at 11:57:58
> In a large analysis of the efficacy of different psychiatric medications, moclobemide scored lowest, below SSRIs. It is simply much weaker than Parnate, Marplan, or Nardil, which had the best results of any drugs, in the same study.
>
> I really wouldn't waste your time on moclobemide. Selegiline/EMSAM is a different thing, however.P-bot,
Actually, a meta-analysis conducted by Lotufo-Neto et al. (1999) found moclobemide to be "somewhat less effective" than the older MAOIs, approximately just as effective as the tricyclics, and, "at the least, comparable to the SSRIs in both efficacy and tolerability." So, even though I agree with your assessment that moclobemide probably wouldn't be a best first choice as far as MAOIs go (especially in the U.S., where EMSAM is available as a "less risky" MAOI), I think that the available evidence suggests that moclobemide tends to be just as effective as the SSRIs (not less effective) in the treatment of depression.
Tomatheus
==
REFERENCE
Lotufo-Neto, F., Trivedi, M., & Thase, M. E. (1999). Meta-analysis of the reversible inhibitors of monoamine oxidase type A moclobemide and brofaromine for the treatment of depression. Neuropsychopharmacology, 20, 226-247.
poster:Tomatheus
thread:676429
URL: http://www.dr-bob.org/babble/20060825/msgs/680157.html