Posted by linkadge on August 25, 2006, at 17:16:21
In reply to Re: about that green tea... » linkadge, posted by Paulbwell on August 25, 2006, at 0:50:28
Yes. Generally when you take some substance that inhibits one pathway of metabolism there is a comepensatory increase in the other metabolic pathways.
Taking selegeline for instance, decreases MAO-B, but it increases DAT. So that the extra dopamine can be taken up by DAT.
Now, if you take a DAT inhibitor like ritaline, wellbutrin, cocaine etc, then you've blocked two pathways for metabolsm.
COMT is another pathway for dopamine and norepinephrine metabolism, so blocking it could be another way to dam up dopamine.
There are a few snags of course. The first being that these pathways are probably designed to prevent excess stimulation of dopamine receptors. There may be a consequence of excess stimulation.
The second snag is that green tea is also an acetylcholinsterase inhibitor. So it can increase acetycholine as well as dopamine. Aceylchonsterase inhibitors can cause depression by thesmeleves in certain people.
Linkadge
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