Posted by jedi on August 21, 2006, at 2:47:41
In reply to Males with atypical depression- TCA or MAOI??, posted by Jimmyboy on August 20, 2006, at 8:30:23
> Ok, one last thing ... Most of the information I saw concerned women wih atypical depression, and not much on males who have it. Also saw some stuff that said women with atypical depression respond better to MAOI;s and men with it respond better to tricyclics. Does anyone have any information on this? Considering I have never tried either , I just really need to know which course to take here. Thanks
Hi,
I have treatment resistant atypical depression with social anxiety. Currently I take 75mg Nardil augmented with 1mg clonazepam. I have tried over 35 different combinations of medications for my atypical depression. Nardil is the only medication that has worked for me. I am male. Most PDOCs are going to take you through several SSRIs, a trial of at least one TCA, probably one of the SNRIs(Serotonin/Norepinepherine) and Wellbutrin or another newer med before they will let you try the MAOIs. If you get the right doctor they may let you skip a step or two. The wrong doctor will not even consider a MAOI.I have read a lot of research on MAOIs and atypical depression. The irreversible MAOIs seem to be the gold standard for treatment of this disease. I haven't read enough about EMSAM to say if it would work for some people. I don't know if the research has been done.
Nardil is going to be more expensive than the TCAs, most of which are out in generic. The market for Nardil is just to small for a generic company to get it approved in the US. I've read that a generic Parnate was just approved by the FDA and should be shipping.
Good Luck,
JediStudies:
Columbia atypical depression. A subgroup of depressives with better response to MAOI than to tricyclic antidepressants or placebo.
Link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8217065&query_hl=8&itool=pubmed_docsumResponse to phenelzine and imipramine in placebo nonresponders with atypical depression. A new application of the crossover design.
Link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2009033&query_hl=10&itool=pubmed_docsumPhenelzine versus imipramine in the treatment of probable atypical depression: defining syndrome boundaries of selective MAOI responders.
Link:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=3278631&query_hl=20&itool=pubmed_docsumDeprenyl in atypical depressives.
Link:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=6430257&query_hl=20&itool=pubmed_docsum
poster:jedi
thread:678298
URL: http://www.dr-bob.org/babble/20060818/msgs/678653.html