Posted by Check on August 15, 2006, at 15:51:34
In reply to Emsam Day 14 - Too soon to tell if it's working?, posted by Ame-Sans-Vie on August 11, 2006, at 6:38:45
> Well today marks two weeks on Emsam 20mg for me. For the first time in years I'm waking up and practically jumping out of bed, ready to go for a jog around the neighborhood and face the day to come. Have cut out caffeine entirely -- I just don't need my morning coffee anymore.
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> Could I really be seeing such a profound improvement in such a short period of time, at this low a dose? I mean, obviously I'm seeing a great improvement, but at this point is it more likely that the drug is doing its intended job, or that the L-amphetamine and L-methamphetamine metabolites are giving me a little "kick"? I know the metabolites are formed in much smaller amounts when selegiline is administered transdermally as opposed to orally, and while I had a response to a combination of oral selegiline 10mg and DL-phenylalanine a while back, it wasn't anywhere near this good.
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> Thoughts, anyone?
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> Cheers,
> MichaelFor what it's worth, my understanding is that the levorotary forms of methamphetamine and amphetamine are either not pharmacologically active or exert effects that pale in comparison to the dextro forms. I agree with other who think that the initial boost is the result of the drug catching your brain off guard. The energizing effect may wear off and be replaced by a true antidepressant effect later as metabolic and receptor changes kick in.
Check
poster:Check
thread:675598
URL: http://www.dr-bob.org/babble/20060810/msgs/676748.html