Posted by SLS on August 12, 2006, at 7:07:59
In reply to Memantine fails to treat depression - NIMH, posted by SLS on August 7, 2006, at 20:21:07
> These same investigators found that memantine, another NMDA receptor antagonist, was ineffective in treating depression.
Despite this, I know of a reputable psychiatrist who is reporting success using memantine in treatment resistant cases. I imagine there are more. It has been used to treat depression occasionally in Germany for at least ten years.
- Scott---------------------------------------------------------
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> : Am J Psychiatry. 2006 Jan;163(1):153-5. Related Articles, Links
> Click here to read
> A double-blind, placebo-controlled study of memantine in the treatment of major depression.
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> Zarate CA Jr, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, Manji HK, Charney DS.
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> Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Human Health Services, Bethesda, MD, USA. zaratec@mail.nih.gov
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> OBJECTIVE: This study was designed to assess possible antidepressant effects of memantine, a selective N-methyl-D-aspartate (NMDA) receptor antagonist in humans. METHOD: In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Primary efficacy was assessed by performance on the Montgomery-Asberg Depression Rating Scale (MADRS). RESULTS: The linear mixed models for total MADRS scores showed no treatment effect. CONCLUSIONS: In an 8-week trial, the low-to-moderate-affinity NMDA antagonist memantine in doses of 5-20 mg/day was not effective in the treatment of major depressive disorder.
poster:SLS
thread:674656
URL: http://www.dr-bob.org/babble/20060810/msgs/675791.html