Posted by linkadge on July 24, 2006, at 20:46:12
In reply to The MAOI of Cannabinoids, posted by SLS on July 24, 2006, at 7:07:16
Yeah, I was reading about URB597.
There are two methods for anandamide metabolism, one being the fatty acid transport, and the other being FAAH, (fatty acid anandamide hydroxylase) (or something). In addition to the FAAH inhibitor URB-597, there are a few other compounds coming out that seem to work as inhibitors of anandamide uptake.
Anyhow, the researchers who immediately discredit the antidepresant effects of cocoa based on the fact that it contains too little anandamide, are not taking into account that cocoa also conatins inhibitors of anandamide uptake.
There are some FAAH inhibitors already available to us. OTC Ibuprofen actually has some FAAH inhibiting properties. If you combine Ibuprofen and dark chocolate (As I was mentioning on the alternative board), you can get quite a buzz.
Also, if you go for some long aerobic exercise, you can extend the blissfull effects by taking an advil aftarwards.
Exercise can boost anandamide levels several fold.
I'd like to get my hands on a URB-597. I really hope this one comes to the market, and doesn't get stopped by some stupid relitively inconsequential hold up.
I don't understand it. Drugs for ADHD have some abuse potential, yet they are still dispensed to children everywhere.
So what if cannabanoid agonists have a small abuse potential, can we not take that risk in order to get some people better for real?
I'd rather be addicted to a drug that works instead of being addicted to paxil.
Linkadge
poster:linkadge
thread:669631
URL: http://www.dr-bob.org/babble/20060724/msgs/670159.html