Posted by JerryPharmStudent on July 6, 2006, at 23:31:56
In reply to buspar+pindolol=very quick and robust AD effect, posted by iforgotmypassword on July 6, 2006, at 22:55:43
> this is at least just one study that said this... my title doesn't reflect my actual opinion, but reflects how little you can say in a short title, but was what the study generally said.
>
> it seemed like a very (very) quick AD combo (probably also anti-anxiety), with AD efficacy maybe even comparable to Remeron+Effexor. just on the basis of quickness it seemed worth trying. maybe some soft experimentation with an anticonvulsant may help stabilize things further, in the event that it did actually work, but not enough.
>
> http://www.biopsychiatry.com/buspfast.htm
>
> "This combination produced a greater than 50% reduction of depressive symptoms in the first week in 8 of 10 patients and the response was sustained for the remainder of the trial. In contrast, the combination of tricyclic antidepressant drugs devoid of effect on the 5-HT reuptake process (desipramine or trimipramine, 75 mg/day for 1 week and 150 mg/day thereafter) with pindolol resulted in only one of ten patients achieving a 50% improvement after 28 days. The combination of the SSRI fluvoxamine (50 mg/day for 1 week and 100 mg/day thereafter) with pindolol produced a marked antidepressant effect but did not act as rapidly as the buspirone plus pindolol combination with none, four, and eight patients achieving a 50% amelioration after 7, 14, and 21 days of treatment, respectively."
>
> kind of unsettling that it seems to endorse the efficacy of a SSRI of all things plus pindolol after 21 days, but for all we know it could actually be that efficacious, being such an uncommonly explored treatment option these days. 5HT-1A stimulation seems to significantly reduce 5HT-2 activity which may have its own hand in it, sort of like its own SSRI+remeron effect (complete with a little alpha-2 antagonism coincidentally). though just based on the specifically unique key actions, and how fast a trial may be conceivably be executed, it sure seems worth trying, maybe even on top of existing meds if you didn't want to take chances with withdrawl effects being in school. in which case i do not know the interaction profile, or what liver enzymes may or may not be relevant, but i am guessing that shouldnt be too hard to find out...
>
> anyways, good luck with school! it is nice to hear from you again!Hey thanks for the info!! I'm doing research for school on BuSpar and any info I can find - especially "real world" experiences are great! I've just had a tremendous response to BuSpar -and perhaps it's partly due to the combined action of the Lexapro and Remeron that I'm currently taking as well?? I certainly think this med is worth a try -especially for treatment-resistant people.
Thanks for the warm welcome back! I realized the other day that I hadn't been to the board in a while. I wanted to come back to help offer knowledge,etc., but also to instill hope in those who have tried everything and don't feel anything will help them. I'm here to say that my depression - treatment-resistant - is finally remitting. And if *I* can get better - after 14 years of meds, ECT, VNS implant and therapy - anyone can!
Warm wishes to you and hope you are well!
JErry
poster:JerryPharmStudent
thread:664294
URL: http://www.dr-bob.org/babble/20060701/msgs/664710.html