Posted by iforgotmypassword on July 4, 2006, at 10:20:16
this is something i am wondering as i am pretty sure i have come to the conclusion that something that is cholinergic or stimulates specifically the anterior cingulate is something i need to try. it seems that it is an essential part of the brain in initiating behavior, deciphering and churning tasks through ones head, executive function and feeling emotions.
one thing i am worried about is if nictonic stimulation along with muscarinic defeats the possibly beneficial muscarinic cholinergic process in any way. one reason i am wondering this was some notes in jay a goldsteins book, and WHY DOES WELLBUTRIN (AN ANTI-NICOTINIC) INCREASE REM?
my plan may be to try aricept with wellbutrin. i will deal with any dysphoric effects this may cause if or as they come, and mainly be keeping close watch on my cognition and emotional capacity.
a big thing that has tipped me off to this is how not only is apathy and poor executive function seeming to be closely tied with the anterior cingulate (ACC), it has been found to be DIRECTLY tied to compulsive hoarding and the hardened, blocked decision making ability that comes with it. this i have down to a T, and i have confirmed this more surely than i have anything. it seems a strange and practically antithetical neurological discovery for symptoms commonly thought tied to OCD symptoms (OCD seems often tied to an strangely functioning ACC, but overactive instead), but one thing that has been known for a long time is that SSRIs are extremely ineffective for hoarding OCD patients, indicating that what SSRIs do for the ACC isnt whats needed (SSRIs seem to reduced activity in the ACC.)
ANOTHER THING THAT TIES ME TO THIS IS THE PARADOXCIAL IMPROVEMENT I GOT UPON COLD TURKEY PAXIL WITHDRAWL. this seems to be related to the ACC and cholinergic function as well which has been documented, AND THIS ALSO PROBABLY EXPLAINS THE DYSPHORIA IN OTHER PEOPLE.
they were studying Reminyl at UCLA for hoarding, but the study now seems to be in limbo. it has shown effective studies to treat bipolar congitive disfunction, though (though HIGH doses were needed; expensive). i worry though, that the nicotinic activity may keep from the whole effect of (muscarinic) cholinergic action, and challenge muscarinic function, and indeed some of the cognitive benefit they recieve may be catecholamergic. (i do not react well or reliably to stimulants, but paradoxically wellbutrin was beneficial after i got used to it (it was hard at first though))
i know aricept has been shown to have positive effects in some people including one very positive case on this board. it is also once daily (pretty important to me)... so i am strongly considering this...
so, not to make this long... but i think anticholinesterase inhibitors are something i need to try. my congnitive hardening makes it impossible to interact with people, tasks and my surroundings. i just need to know what is best to try... i am thinking wellbutrin plus the ARICEPT at higher doses is what i should try. and leave my leftover galantamine (non-rx supplement version) for another try if i need to, as currently i cant even remember to take it as often as it's short half-life demands.
thank you for reading this and ANY input would be very much appreciated. this was very difficult to type.
poster:iforgotmypassword
thread:663955
URL: http://www.dr-bob.org/babble/20060701/msgs/663955.html