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Re: link to article regarding effects of MPH on heart » linkadge

Posted by saturn on July 3, 2006, at 15:05:32

In reply to Re: link to article regarding effects of MPH on heart, posted by linkadge on July 1, 2006, at 0:30:17

> Some of these problems may only manifest long down the road. The cardiac changes that were observed in mice can only be found post mortem.

Hey link,

Actually, it seems the changes appeared rather quickly. The following statements were in the first article:

“Also noteworthy was the rapid development of pathological changes (i.e., within 3 weeks). “

“The rapid appearance of lamellar structures, coupled with the potential for irreversibility and the profound structural changes seen in a patient on long-term MPH therapy, suggests that these findings may have clinical consequences for drug interactions and long-term side effects of MPH of which clinicians should be aware. “




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