Posted by bassman on July 1, 2006, at 16:55:54
In reply to what's latest consensus Lexapro:Celexa ratio 2:1??, posted by qbsbrown on July 1, 2006, at 3:06:04
I think the answer is 2:1 based on being a pharmaceutical chemist for 25 years and stuff like this:
The editors of The Medical Letter on Drugs and Therapeutics concluded in their September 30, 2002, review of the drug that: “Escitalopram (LEXAPRO), the active enantiomer [one of the two mirror images] of citalopram (CELEXA), is effective for treatment of depression, but it has not been shown to be more effective, more rapid-acting or less likely to cause adverse effects, including sexual dysfunction, than citalopram or any other SSRI.”1
I also finding it very telling that the Remedyfind.com site, with 1500 users evaluating Celexa versus Lexapro for depression, end up with them being equally effective and the average Celexa user uses twice the dose of the average user of Lexapro.I find the case very compelling for Lexapro simply being the bioactive of the two isomers of Celexa, which are each present at 50%- and therefore the efficacy ratio is 2:1.
For a completely different opinion, see (on this site):
poster:bassman
thread:663181
URL: http://www.dr-bob.org/babble/20060701/msgs/663303.html