Posted by Donna Louise on June 23, 2006, at 6:25:05
In reply to Re: correcting myself » Donna Louise, posted by SFY on June 22, 2006, at 23:39:07
> > I was afraid I said something wrong when I said that nortrip did not effect serotonin. I went to crazy meds, which is easy to read , and found there that it is a mild serotonin reuptake inhibitor and a moderate one for norepinephrine. It is like a newer version of Elavil (still it has been around since 1964) and has fewer hits at the histamine receptor so not as bad side effects. Also, "less likely to mess with your heart than other TCA's." Also "regular blood tests are needed for doses greater than 100mg a day." It didn't say why though. I guess I need more info about that.
> > Anyway, I wanted to correct that it does have a mild effect on serotonin reuptake.
> >
> > donna
>
> There might be some dosage issues calling for regular blood tests for high Nort dosing but I don't recall seeing a specific requirement. However, because Nort has a narrow therapeutic window, if you're on a high dose you want to get a blood test to make sure that your blood levels don't exceed the upper limit of that window. When your blood level gets too high, Nort loses its efficacy.
>
I believe it said that 150 was a toxic dose, and if that is the case, maybe it is a way too to check to make sure that level is not being reached due to liver metabolism being sluggish.donna
poster:Donna Louise
thread:657616
URL: http://www.dr-bob.org/babble/20060623/msgs/660491.html