Posted by willyee on June 9, 2006, at 16:28:13
In reply to Klonopin Mechanisms?, posted by blueberry on June 9, 2006, at 15:53:08
> Other than working on GABA, what else does klonopin do? I have heard that it affects serotonin receptors, but I don't know which ones or how it affects them. Not sure how it might affect dopamine or norepinephrine other than dampening them down or slowing their release. Just guessing. Any detailed info on klono mechanisms?
I have a folder where i save information as i come across it that i find valuable.I saved this article on Klonpin years & years ago.
I cant verify the source,of how accurate the information is cause the link attatched is so old its no longer valid,however i doubt the person just made it up,just doesent sound like something anyone would,anyway this is the exact snippet i have saved in my folder,again the link is very old and outdated and does not work,however its the only more throuough explanation of klonopin ive heard before.Here it is............
"I did a search and found clonazepam:
Clonazepam was introduced in the US in 1976 and in
Japan in 1981. The mechanism of clonazepam's ac-
tion has not yet been established. With a high affinity
for central benzodiazepine receptors, clonazepam is
a facilitator of gamma-aminobutyric acid system, and
also increases central synthesis of serotonin,
dopamine and noradrenaline, and mimics the effect of
the neurotransmitter glycine. This is a combination
of effects that may offer antidepressive action.
Clonazepam has been recognised as a useful augmen-
tation (i.e. adding a medication onto the existing, on-
going drug treatment) for the treatment of
prolonged depression.
http://www.depression.org.uk/main/pdf/treatmedication8.pdf
"
poster:willyee
thread:654917
URL: http://www.dr-bob.org/babble/20060604/msgs/654932.html