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Re: MAOI and epinephrine

Posted by Karen44 on June 8, 2006, at 22:39:25

In reply to Re: MAOI and epinephrine » SLS, posted by Caedmon on June 8, 2006, at 18:21:42

> Hey Scott,
>
> Excellent question. It looks like I was only *kind of* right. Here is what I came up with:
>
> ~~~
>
> Anaphylaxis and monoamine oxidase inhibitors—the use of adrenaline
> M J Fenwick and C L Muwanga
> J Accid Emerg Med 2000; 17:143-144
> http://emj.bmjjournals.com/cgi/content/full/17/2/143 [link to full text]
>
> ~~~
>
> There is also this:
>
> "It is unclear if there is an interaction between MAOIs and vasoconstrictors. The termination of the pharmacological response to epinephrine is not primarily dependent on monoamine oxidase. Thus, exogenous epinephrine should not be appreciably affected by the administration of a MAOI. In one study, four healthy subjects took MAOIs and were given IV epinephrine. No significant effect on heart rate or blood pressure occurred. This same study also showed no interaction between norepinephrine and MAOI. Hansten and Horn have reported that MAOIs may slightly increase the pressor response to norepinephrine and epinephrine, an action which appeared to be due to receptor sensitivity caused by the MAOI (Drug Interactions and Updates, PD Hansten and JR Horn (eds.), 1990, Malvern, PA: Lea and Febiger) It is currently accepted practice to use caution when administering local anesthetic with vasoconstrictor in patients medicated with MAOIs."
>
> - http://www.lexi.com/web/dentistry.jsp?id=wynn_january06
>
> ~~~
>
> - Chris

Thanks for the responses. I can't find the citation I had seen, but I will ask my psychiatrist tomorrow when I see him. He has published some sort of disc related to drug interactions.

Karen


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URL: http://www.dr-bob.org/babble/20060604/msgs/654686.html