Posted by SLS on May 30, 2006, at 11:09:36
In reply to Re: hint on last thread (SLS?) » SLS, posted by idolamine on May 30, 2006, at 10:51:26
> Hey scott- thanks again!
>
> I would descrive the hyperkinesia not in terms of jerks or hyperactivity, but the execution of planned motor movement. Almost a manic state, but not of mind, of motor movements, where you start to execture behaviour towards a goal, and then switch spontaneously a few seconds into it, and in your mind, you can't apply the brakes. I've reduced my lamictal dose and it seems a little better. Would you consider it reasonable that too much glutumate could produce this? thanks so much.With hyperlocomotor states, one usually thinks of dopamine.
Lamictal is thought to reduce glutamate, not increase it. One would think that reducing the dosage of Lamictal should allow for an increase in glutamate. I have a hunch that Lamictal increases dopaminergic neurotransmission indirectly. It is not unusual for people to react to Lamictal with psychomotor activation, anxiety, and mania. If Lamictal makes you feel worse, perhaps Provigil would make you feel better. It increases glutamate. You might want to try some magnesium and see how you react to it. Magnesium can produce a calming effect, perhaps acting to block NMDA receptors. If, instead, you react to it in a manner similar to Lamictal, you might indeed have underactive NMDA receptors.
Have you ever tried taking a neuroleptic antipsychotic?
- Scott
poster:SLS
thread:650135
URL: http://www.dr-bob.org/babble/20060530/msgs/650432.html