Posted by bassman on May 28, 2006, at 10:40:01
In reply to Re: Is it safe to cut Wellbutrin SR??, posted by KayeBaby on May 28, 2006, at 10:23:50
http://us.gsk.com/products/assets/us_wellbutrinSR.pdf
“a study comparing chronic dosing with
WELLBUTRIN SR Tablets 150 mg twice daily to the immediate-release formulation of
bupropion at 100 mg 3 times daily, peak plasma concentrations of bupropion at steady state for
WELLBUTRIN SR Tablets were approximately 85% of those achieved with the
immediate-release formulation. There was equivalence for bupropion AUCs, as well as
equivalence for both peak plasma concentration and AUCs for all 3 of the detectable bupropion
metabolites. Thus, at steady state, WELLBUTRIN SR Tablets, given twice daily, and the
immediate-release formulation of bupropion, given 3 times daily, are essentially bioequivalent
for both bupropion and the 3 quantitatively important metabolites”.
Sounds like the two pdocs were right; cutting in half is O.K.I had to toss this in about Wellbutrin from Crazymeds.org:
Wellbutrin / Wellbutrin SR / Wellbutrin XL's Not So Common Side Effects: Strange body odor, sweating, nervousness and tremor. Basically Wellbutrin could make you look like the guilty party, so you better have a damn good alibi at all times in case some big, unsolved crime goes down.
poster:bassman
thread:648924
URL: http://www.dr-bob.org/babble/20060525/msgs/649669.html