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Re: How long have MAOI's been used for?

Posted by Jost on May 19, 2006, at 22:20:30

In reply to Re: How long have MAOI's been used for? » JaclinHyde, posted by Declan on May 19, 2006, at 21:41:25

Another website offered this information:

" Iproniazid was found by chance to have a marked effect on depressive symptoms in TB patients, so much so that it was soon superseded by another less stimulating drug, (and finally withdrawn by the manufacturers in 1961, when found to cause liver damage):

"It was eventually displaced by isoniazid since iproniazid actually made some of the patients feel ‘too well’ with the result that they failed to observe ordinary precautions, overexerted themselves, or discontinued treatment prematurely. Retrospectively it is evident that the drug not only relieved depression but occasionally must have induced euphoria. In view of the excessive good spirits of the patients it is strange that at the time the emotional reaction was regarded as a detrimental side effect and no one tried using iproniazid for treatment of depression". (Kline, 1964)"

My understanding was that various reported instances of hypertensive crises, which were not fully evaluated and studied, caused most physicians to reject maois. At least until more recently.





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