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Re: What does half-life really mean? » Larry Hoover

Posted by flip_flop on May 14, 2006, at 2:17:21

In reply to Re: What does half-life really mean? » flip_flop, posted by Larry Hoover on May 13, 2006, at 9:10:50

OK, but is it always necessary to maintain stable blood concentrations of a drug? Seroquel, for example, is often taken in low doses for other disorders than schizophrenia. It has a short half-life and has to be taken several times/day. Unfortunately it's very sedating, which prevents some people from taking it in the daytime. But what if someone took a large enough dosage only at bedtime? This way the sedation might wear off, and the drug would be effective throughout the next day. Maybe it's not necessary to maintain stable concentrations of Seroquel when taken for other disorders than schizophrenia?


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