Posted by Larry Hoover on May 11, 2006, at 15:00:06
In reply to is modafinil metabolized by CYP450?, posted by saturn on May 11, 2006, at 14:21:58
>
> The monograph says a lot about oxidation, glucoronidation and so forth...but is this via CYP450 metabolism? 2D6?I'm not sure if we're reading the same monograph, or not, but the one I'm reading specifically mentions the enzymes, under drug-drug interactions.
http://www.rxlist.com/cgi/generic2/modafinil_cp.htm
At least 90% of the drug goes through CYP450, and yes, 2D6 is a major route. Note also that it induces 3A4, so you get the anti-grapefruit effect. It mentions 2C9, 2C19, also. Both of those have metabolic variants, like 2D6. This drug could be very different things to different people, depending on their genetic complement of CYP450 enzymes.
Lar
poster:Larry Hoover
thread:642664
URL: http://www.dr-bob.org/babble/20060510/msgs/642675.html