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Re: DAT knockout mice less depressed that SERT kno » linkadge

Posted by zeugma on May 1, 2006, at 16:12:28

In reply to Re: DAT knockout mice less depressed that SERT kno, posted by linkadge on May 1, 2006, at 15:46:53

> I don't really know why we have not persued other DAT inhibitors as antidepressants. I guess we just assumed that serotonin was the main culprit.
>
> I remember reading that SSRI's were only very weakly active in forced swim tests in mice.
>
> Linkadge

that is true, and is in fact one of the reasons Lilly took so long to develop fluoxetine as an AD. for a while, those that considered them, in fact, AD's thought they were 'false negatives' in the FST.

SSRI's are active in such tests but rats display different behavior: on TCA's or other NE potentiating meds the rats try to climb out of the glass cylinder, while on fluoxetine etc. they swim.

amphetamine has long been known as a 'false positive' in the test. so has atropine. i believe both produce climbing, behavior more typical of NE than 5HT meds.

-z


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