Posted by linkadge on April 23, 2006, at 12:48:44
In reply to Re: Another drug failure » SLS, posted by linkadge on April 23, 2006, at 12:28:56
How do you feel about the abilify. The reason I ask is that it does have a strong antagonistic affinity for d3 receptors. These receptors are loaded in pleasure centres of the brain. So I don't know the kind of effect that blocking those would have on anhedonia.
The theraputic effect you're getting from this drug is probably a combination of 5-ht2a antagonism and 5-ht1a agonism, and perhaps d2 agonism.
The combination of dopamine + serotonin agonism is an unexplored terrain. For instance one study showed that (in parkonsons disease) adding gepirone to a dopamine agonist resulted in significant improvements in both movement and depressive symtpoms.
Ie buspar + mirapex.
What about replaceing the abilify with trazodone ?
Lamictal + trazodone + nortryptaline.
It might be cleaner.
Linkadge
poster:linkadge
thread:635786
URL: http://www.dr-bob.org/babble/20060423/msgs/636183.html