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Re: atenolol vs metoprolol SLS

Posted by saturn on April 18, 2006, at 17:08:41

In reply to Re: atenolol vs metoprolol, posted by SLS on April 18, 2006, at 6:54:42

> I really can't compare and contrast the two drugs, but was wondering if you had looked at Coreg (carvedilol). It is good for both hypertension and heart failure. I'm not sure about angina.
> - Scott

Hi Scott,

Yeah, I've checked into Coreg as you've mentioned, but I prefer not to take it due to it's non-beta selectivity. I really appreciate the suggestion, however.

(BTW...I've just changed my posting name from mike99 to saturn).

> > I have a few questions regarding differences between the two if anyone would care to answer.
> >
> > Here is what I understand the differences between atenolol and metoprolol to be (please correct me if I'm wrong):
> >
> > While both are cardioselective, atenolol tends to lose this selectivity much more easily than metoprolol at increased doses.
> >
> > Metoprolol is more liphophilic--so it penetrates the brain more easily and therefore may be more likely to cause sedation/depression/cognitive problems than atenolol.
> >
> > Metoprolol: the only beta blocker proven for treatment of angina, high blood pressure and heart failure. I also found an article called "Time to Reconsider Atenolol?" suggesting atenolol may not have many other cardioprotective benefits which metoprolol possesses.
> >
> > Atenolol: Not metabolized by liver, longer acting
> > Metoprolol: Metabolized by liver, shorter acting
> >
> > Are there any other significant differences I should know about (perhaps in terms of ED, lipid effects, insulin resistance, exercise tolerance...others)? Is tolerance or dose escalation more likely with one than the other?
> >
> > It seems atenolol may have the upper hand in terms of CNS effects but metoprolol may be better on the whole for the heart???
> >
> > OK I will stop with the million questions. Just wondering if there are any important differences of which I should be aware. I'd greatly appreciate any feedback. Peace out.
> >




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