Posted by linkadge on April 10, 2006, at 15:24:19
In reply to Re: Parnate is often augmented with Lithium, posted by Caedmon on April 10, 2006, at 14:20:35
That study doesn't comment on the doses of the drugs used. Lithium is a 5-ht1b autoreceptor antagonist. It causes a release of serotonin in certain parts of the brain.
With less MAO-A to metaboloize it, the serotonin can accumulated to toxic levels leading to serotonin syndrome.
The pharmacy (shoppers drug mart) is geared with an interaction checker. This is a potential interaction. I'm sure you can find studies that suggest that certain populations respond to SSRI + MAOI combinations, but that doesn't negate the fact that there is a potential for interaciton.
I'm not saying never do it, I am just saying be carefull.
I guess the point I was trying to make was that my doctor was unaware that there was a *potential* for interaction. When the pharmacy questioned him he checked his books and decided not to go through with the combination.
poster:linkadge
thread:630791
URL: http://www.dr-bob.org/babble/20060408/msgs/631455.html