Posted by tessellated on March 15, 2006, at 1:17:52
In reply to Re: NYTIMES- Attention Surplus?Re-examining a Diso » Chairman_MAO, posted by mike99 on March 11, 2006, at 19:53:20
i've used both parnate and provigil on and off quite effectively for over four years. recently i've even been augmenting parnate with provigil. (i don't recommend this at all-it gave me some form of heart burn).
provigil is great because i find it relatively clean and even mild. its easy to pick and choose other forms of augmentation, and i wouldn't even say i feel in any way "drugged/altered" by it
parnate in my mind is a radical philosophy. it alters the very fabric of my personality-positively. parnate is a total lifestyle change. diet (is not a big deal) but the radical way its alters much of your sympathetic nervous system exponentially complicates the use of any and all concurrent medications.
personally, i've yet to get much of anything aside from increased libido from selegeline.
parnate is an adventure its alters the matrix of my reality and adds excitement to life. provigil is does none of that, but is great for fatigue and all nighters. provigils beauty is that is not radical.
as parnates chemical structure is similar to amphetamine it would likely have similar benefits for ADD/ADHD. it really just depends on how radical a departure you want to make. i think parnate is vastly preferrable to amphetamine and far more profound.
profound isn't always preferrable though....
i belive parnate would help with both ADHD and dysthymia, though it does also radically compromise the stability of sympathetic nervous system. personally i experience mild orthostatic hypotension, not hypertension. however parnate is is contraidicted as follows:
In patients with cerebrovascular defects or cardiovascular disorders
PARNATE should not be administered to any patient with a confirmed or suspected cerebrovascular defect or to any patient with cardiovascular disease or hypertension.
however, they also tell you not to eat banana peels, so i take everything with a salt lick when it comes to MAOI's anymore.
> > You would probably fare better on tranylcypromine (or selegiline) than Provigil. IMHO its use for concentration problems is ill-founded.
> > If you want to try an MAOI for attention/concentration problems, I'd suggest first going with the selegiline patch at the lowest dose.
> Why not Parnate first? An MAOI is something I never thought I'd seriously consider, but given the buzz they've been getting here on PB I'm reconsidering. If an MAOI would hit my ADHD and dysthymia AND I could tolerate it from a cardiovascular standpoint (biggest if) might give it a shot.
> If you don't mind, Chairman_MAO, may I ask you a few further questions regarding them? (I take no offense if you're too busy to respond or don't know).
> Do you really think Parnate would be a better choice for ADHD than Modafinil (you're probably aware it's recently received an FDA indication for ADHD)?
> Might you know how MAOI's (selegiline not included) compare to Ritalin and Dex in terms of peripheral/cardiovascular stimulation? Caffeine, Provigil?
> Do MAOI's have more or less of a propensity to poop out than the other AD's?
> Do you know if Nardil or Parnate would have more or less peripheral/cardiovascular stimulation than the selegiline patch? (I ask this because seligline is converted to Meth and AMP, though I believe this conversion is extremely minimal)?