Posted by Chairman_MAO on March 7, 2006, at 15:12:19
In reply to The 'new' Nardil » Chairman_MAO, posted by ed_uk on March 7, 2006, at 14:22:27
I agree. At times I was tempted to go beyond 1mg/kg/day or try bioavailability enhancing strategies in order to ensure that I got as much benefit as the "old" Nardil was supposed to give. However, too much MAO inhibition causes a drastic fall in dopamine synthesis, viz. a very high dose of phenelzine may provide as much benefit as not enough. I found I felt better at 1mg/kg "straight up". One problem I think people may have is not taking it tid-qid. The half-life is only 2-3 hours, and there is definitely an acute anxiolytic effect not related solely to MAO inhibition. Perhaps this has to do with the pharmacokinetics of its GABA-T-inhibiting metabolite or the formation thereof. I don't know.
poster:Chairman_MAO
thread:614817
URL: http://www.dr-bob.org/babble/20060304/msgs/617094.html