Posted by yxibow on March 5, 2006, at 4:25:01
In reply to Re: NASA's , SSRI, SNRI, etc. » yxibow, posted by Phillipa on March 4, 2006, at 18:46:13
> Stupid question from stupid me but if they are in your gut how do they affect you brain and depression remember I can be an imbacile. Love Phillipa
Remember the old phrase "gut instinct" ? For whatever reason, and I can only place this if one believes in evolution, genetics somehow could not fit much of the serotonin receptors in an average sized brain. So they ended up in the gut, a great percentage of them. Especially 5HT3, responsible for nausea and vomiting and the like. Ginger is a weak 5HT3 inhibitor, the older Tigan and the new 5HT3 blockers ondansetron and granisetron (and tropisetron outside of the US) are heavy 5HT3 blockers. Its the reason why earlier "unclean" SSRIs initially affect people in the stomach largely until they become accustomed to the nausea. Perhaps it was an early defense system -- your gut is a pretty powerful feeling. Serotonin itself cannot pass the blood brain barrier and largely circulates in your blood stream. Its precursor components such as 5HTP can though.
poster:yxibow
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URL: http://www.dr-bob.org/babble/20060304/msgs/616106.html