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Re: FDA Approves EMSAM... dosage? » gibber

Posted by jrbecker on February 28, 2006, at 21:39:13

In reply to Re: FDA Approves EMSAM... dosage?, posted by gibber on February 28, 2006, at 18:18:33

> I thought the dosages were 20,40,60 mg/day. It seems that they are 6,9, and 12mg/day...I'm sure this is not a last minute change. I suppose 6mg of transdermal is like 20mg of oral tabs. Am I right?


Actually there's really no difference than those dosages done in the clinical trials (20, 30, 40). I guess they're now measuring transdermal dose absorption [time] rate versus before they spoke of it in terms of dosage by patch area... ...see link above for the product's prescription information/product insert. The following quote from it might explain the discrepancy...

"EMSAM systems are transdermal patches that contain 1mg of selegiline per cm2 and deliver
approximately 0.3mg of selegiline per cm2 over 24 hours. EMSAM systems are available in three sizes: 20mg/20cm2, 30mg/30cm2, and 40mg/40cm2 that deliver, on average, doses of 6mg, 9mg or 12mg, respectively, of selegiline over 24 hours."



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URL: http://www.dr-bob.org/babble/20060227/msgs/614480.html