Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Ending Nardil and Doc prescribed selegiline

Posted by gibber on February 23, 2006, at 12:04:07

Hey y'all,
I wanted to let you know that my nardil trial ended after 3 months. I was very optimistic about its success, but it didn't really turn out as I expected. I would say it was probably the best AD I have tried, and improved my depression maybe %25. THis is more than any other med I have tried. The side effects of insomnia and sexual dysfunction were particulary bad.
Without too much persistence I was able to get my doctor to prescribe selegiline and presented him with research on PEA and selegiline treatment. He wasn't familar with this combination, but is ok with me trying it. This research I have read on this combination has been very encouraging and I just hope it works for me!!! Below I found another great article, I'll post an exerpt from it too. Interestingly one study combined 5-HTP with selegiline, something I think is contraindicated in some literature.

http://p078.ezboard.com/fthepeacockchroniclefrm24.showMessage?topicID=9.topic

DEPRENYL: DEPRESSION

Deprenyl has been used experimentally as a treatment for depression
since the late 1970s. While the causes of depression are diverse and still
under investigation, it is by now accepted that dysfunction of dopamine
and noradrenalin neural systems is a frequent biochemical cause of
depression. (18,19)

In addition the research of A. Sabelli and colleagues has established that a
brain PEA deficiency also seems to be strongly implicated in many cases
of depression. (32) Given that deprenyl is a catecholamine (dopamine and
noradrenalin) activity enhancer, and that deprenyl strongly increases brain
PEA through MAO-B inhibition, deprenyl would seem a rational treatment
for depression.

Studies with atypical depressives (33), treatment-resistant depressives (34),
and major depressives (35) have shown deprenyl to be an effective, low
side-effect depression treatment. However, such studies have often
required deprenyl dosages in the 20-30, even 60 mg range. While these
dosages caused little problem in short-term studies, it is dubious to
consider using such high, non-selective MAO-B inhibition doses for long
term (months - years) treatment. Three studies have shown
antidepressant promise at selective, MAO-B inhibiting doses.

In 1978 Mendelwicz and Youdim treated 14 depressed patients with 5 mg
deprenyl plus 300 mg 5-HTP 3 times daily for 32 days. (1) Deprenyl
potentiated the antidepressant effect of 5-HTP in 10/14 patients. 5-HTP
enhances brain serotonin metabolism, which is frequently a problem in
depression (37), while deprenyl enhances dopamine/noradrenalin activity.
Under-activity of brain dopamine, noradrenalin and serotonin neural
systems are the most frequently cited biochemical causes of depression
(18,19,37), so deprenyl plus 5-HTP would seem a natural antidepressant
combination.

In 1984 Birkmayer, Knoll and colleagues published their successful results
in 155 unipolar depressed patients who were extremely
treatment-resistant. (8) Patients were given 5-10 mg deprenyl plus 250 mg
phenylalanine daily. Approximately 70% of their patients achieved full
remission, typically within 1-3 weeks. Some patients were continued up to
2 years on treatment without loss of antidepressant action. The
combination of deprenyl plus phenylalanine enhances brain PEA activity,
while both deprenyl and PEA enhance brain catecholamine activity. Thus
deprenyl plus phenylalanine is also a natural antidepressant combination.

In 1991 H. Sabelli reported successful results treating 6 of 10
drug-resistant major depressive disorder patients. (9) Sabelli used 5 mg
deprenyl daily, 100 mg vitamin B6 daily, and 1-3 grams phenylalanine
twice daily as treatment. 6 of 10 patients viewed their depressive episodes
terminated within 2-3 days! Global Assessment Scale scores confirmed
the patients’ subjective experiences. Vitamin B6 activates the enzyme that
converts phenylalanine to PEA, so the combination of low-dose deprenyl,
B6, and phenylalanine is a bio-logical way to enhance both PEA and
catecholamine brain function, and thus to diminish depression.


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:gibber thread:612450
URL: http://www.dr-bob.org/babble/20060219/msgs/612450.html