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Re: akathisia?

Posted by SLS on February 17, 2006, at 9:12:58

In reply to Re: akathisia? » James K, posted by yxibow on February 17, 2006, at 2:48:37

I found that Abilify produced a "restlessness" that was uncomfortable, but not debilitating. This phenomenon pretty much disappeared within the first 1-2 weeks. It did not escalate once it appeared, but rather, showed signs of abatement. The only thing I can attribute this experience to is a mild akathisia-like syndrome that Abilify seems to be particularly apt to produce.

Recently, it seems to me that people are too quick to conclude that whatever agitation or anxiety they feel with a new drug is akathisia. Akathisia with drugs other than neuroleptic antipsychotics is very infrequent, if not rare. Prozac might be the worst offender of the SSRIs. However, Abilify has been all but determined to precipitate akathisia on a regular basis. I forget the theory as to why it carries this liability, but the early predictions of this EPS seem to be born out in real world experiences. That abnormal movements are not seen often with Abilify is the result of its not penetrating or accumulating in the striatum.


- Scott

 

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