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Re: two other factors? » linkadge

Posted by zeugma on February 12, 2006, at 15:29:29

In reply to Re: two other factors?, posted by linkadge on February 12, 2006, at 15:09:06

> No, but it just makes one wonder. I remember doing a small poll in one of my classes. 1/4 of the class was on antidepressants.
>
> I remember saying to myself, what the f*ck ?

perhaps your classroom is an unrepresentative sample (just kidding).

but about neuroprotection and antidepressants:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11850470&query_hl=15&itool=pubmed_docsum

this study claims that amitriptyline decreased age related impairments in water maze learning in rats. The same researchers then showed that fluoxetine failed to produce beneficial effects using the same parameters:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12393271&query_hl=17&itool=pubmed_docsum

So are we to conclude that tianeptine, amitriptyline, lithium, but not fluoxetine are neuroprotective?

Anecdotal evidence: I am certain that my performance on spatial tasks has improved tremendously since starting my current regime of nortriptyline three and a half years ago. Extrapolating from my own experience, or that of tree shrews or aging rats, has its dangers. But we do have to decide what evidence we are to take seriously and what disregard, and our own experiences usually cast the final vote in these matters.

-z
>
> Linkadge


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poster:zeugma thread:608339
URL: http://www.dr-bob.org/babble/20060212/msgs/608962.html