Posted by the kindling effect on February 9, 2006, at 11:27:10
In reply to Re: Akathisia vs. Tardive dyskinesia » fenix, posted by yxibow on January 31, 2006, at 1:20:49
> > Akathisia is not short for tardive akathisia. Tardive akathisia is something different. Tardive is derived from the Latin word meaning late onset.
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> > Tardive akathisia differs from normal akathisia because it 1) lasts for a very long time (if not indefinitely) even when the drugs that caused it are stopped and 2) has a tendency to be extremely difficult to treat; drugs such as propranolol (which is very effective in temporary neuroleptic-induced akathisia, usually does nothing for tardive akathisia), benzodiazepines, opiates, dopamine depleters (such as reserpine), and divers other things have proven unsatisfactory results.
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> You might look into wemove.org and other sites devoted to movement disorders. I can't discuss importation of drugs here, but people have imported Tetrabenazine (Nitoman in Canada) from Canada and England. It is considered a fast track orphan drug by the FDA currently. A company has filed a NDA recently to have it approved in the US for Huntingtons Chorea. It has been used in trials for TD in the same way reserpine has been used. It can cause pseudoparkinsonism, but one has to weight the benefits.
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Depression and pseudoparkinsonism are the main two for Tetrabenazine. We have it here in Canada as you mentioned. Apparently it's not a nice drug if you already suffer depression ,anxiety etc. My rough understanding is reserpine is sort of irreversible DA depleter whereas tetrabenazine is reversible (think Moclobimide versus standard MAOIs perhaps). Dysphoria,anxiety,insomnia etc. are other side effects. This is my treatment option I've been given right now but I'm told I need to start in hospital due to possibility of becoming suicidal(more?) and due to side effects. I also believe you must request the drug from government under 'compassionate plea' request (something along those lines. I've been told I have mild chorea or (something that imitates it neurologists have differing opinions) but most say it is the akathisia when I'm under stress and staying still. Along with vatious tics. Huntington's isn't pretty o see. I've already been ruled out for Wilson's and Huntington's.
Nitoman.(always think of Bart Simpson; ie 'neat-o man!' 'not sure how it's supposed to help dysphoria when it can cause it. (rhetorical. No theories or suportive comments please.)
poster:the kindling effect
thread:604046
URL: http://www.dr-bob.org/babble/20060205/msgs/607922.html