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Please help - Weird response to Lithium

Posted by rbean on January 28, 2006, at 23:35:19

Hi,
I just started on Lithium (lithobid) a few days ago for BP II. Since I've been on it at 300mg a day I've just felt like climbing the walls. I have very little appetite, I fidget constantly, and just have constant highly unpleasant and fairly disabling inner tension. I have no interest in doing much of anything except distracting myself from this feeling and I can barely sleep at all even with 300 mg trazodone.

Has anyone ever heard of this or have any ideas? I'm supposed to increase my dose to 300 mg bid, but I'm afraid to. I feel like this is kind of frying my brain. Kidneys check out okay. I should not be toxic at this dose. I do have a history of being sensitive to low doses of medication. I've read a little about glutamate and lithium. In mice, lithium acutely inhibits glutamate uptake, increasing glutamate in the synaptic cleft, though chronically given it modulates glutamate uptake. THis feels like the sort of activation that an excitatory neurotransmitter like glutamate would give. But glutamate is neurotoxic, so yikes.


I'd love some suggestions if anyone has any.

Thanks a lot,

Becca


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poster:rbean thread:603972
URL: http://www.dr-bob.org/babble/20060122/msgs/603972.html