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Zyprexa and Metabolic Syndrome

Posted by thebends on January 23, 2006, at 14:29:11

Hi all. I posted here a while back about medication for intractable OCD. In the interim, I was given a presumptive diagnosis of comorbid Bipolar II. My current doctor recently started me on a cocktail of Prozac (40mg), Lamictal (50mg), and Zyprexa (2.5). He now wants to raise the dose of Zyprexa to 5mg to help me deal with contamination obsessions that, frankly, border on delusional. I initially opposed the addition of the Zyprexa in the first place due to concern over the possible metabolic effects. Specifically, I was concerned that the Zyprexa would have a ruinous effect on my physique, or worse, would cause me to become insulin resistant. In reality, I really have no context for these fears: How long does it take for "metabolic syndrome" to develop? Does everyone develop it? Are there any outward signs of developing it? Is any damage done irreversible? I should also mention that my maternal grandfather suffers from diabetes type II. Given my concerns and family history, would it not make more sense to try one of the other APs less likely to cause metabolic problems, e.g. Risperdal, Geodon, etc.? I think he is partial to the Zyprexa because it has mood-stabilizing properties, and according to him is "best for quasi-delusional thoughts," but are the other APs really any less effective? For what it is worth, I do not think he intends to keep me on the Zyprexa long-term, and in fairness, I have not noticed any weight changes or change in appetite in the two weeks I have been on the Zyprexa, but I am still concerned over any possible short term effects. I would like to hear from any one with comments or suggestions. Thanks in advance.


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poster:thebends thread:602106
URL: http://www.dr-bob.org/babble/20060122/msgs/602106.html