Posted by linkadge on December 27, 2005, at 21:32:18
In reply to Re: What to do if Nardil and Parnate were discontinued » ed_uk, posted by Tomatheus on December 26, 2005, at 23:03:27
But moclobemides lack of efficacy may be more due to the fact that it inhibits the MAO-A enzyme reversably, as opposed to nardil and parnate.
Nardil and parnate, also have some secondary properties which may boost their antidepressant efficacy.
Nardil affects gaba, and parnate actually does some weird things with monoamine transporters (it acutally poseses some serotonin uptake inhibition)
Cause, I think we have some irreversable inhibitors of MAO-A, that are more effective than moclobemide.
Linkadge
poster:linkadge
thread:591969
URL: http://www.dr-bob.org/babble/20051221/msgs/592621.html