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Re: Personal experiences with Zyprexa and EPS, a ? med_empowered

Posted by yxibow on December 21, 2005, at 0:33:36

In reply to Re: Personal experiences with Zyprexa and EPS, a ?, posted by med_empowered on December 20, 2005, at 23:35:30

> hi! My experience with zyprexa was short-lived--2.5mgs/day gave me **pronounced** akathisia (shaking, fidgeting, hellish anxiety), so that was pretty much that.

Really.. that's quite surprising, I would rate atypicals in increasing order of EPS (esp. akathisia) as:

Clozaril
Seroquel
Zyprexa
{Geodon, Abilify}
Risperdal

Sometimes pseudoparkinsonism does go away with treatment...I think this usually happens within the first month of treatment.

Yes.. this I've vaguely heard

>
> I personally would not recommend doing Zyprexa again.

I know... its just that it had a profound effect... I'm debating but I'm not doing anything at the moment

Abilify might be a good option.

Abilify was disappointing, I waited for it to come out and it produced akathisia just like Geodon, maybe a tad less

Seroquel is a good one, too.

Which I take at bedtime 900mg.

Maybe you could do low-dose seroquel, plus low-dose abilify?

Possibly lower dose abilify I could stand, I dont know, but I dont know if it has the same D2 and 5HT2a profile that Zyprexa has

Geodon is also usually pretty good with EPS, but tends to be pretty heavily sedating.

Definately not sedating in me... I was writhing in akathisia grabbing the carpet, literally

>
> Have you considered Surmontil? Its kind of like a low-grade antipsychotic; it seems to be kind of clozapine-ish in its mild D2 dampening effect. I would imagine that might help you a bit. Plus, it doesn't seem to cause many EPS problems until the doses get crazy high, and I don't think TD is a big problem, either.

TD does occur with tricyclics, although far less than antipsychotics, probably on the order of Zoloft.

The theory of clozapine related effects are more in-vitro than in-vivo, not nearly as proven as antipsychotics and of course added to my regime would make me a zombie as they're generally very to somewhat sleep inducing, or sweat-making, or something else... they're not as clean as SSRIs. I also currently take Cymbalta. But it is curious information about it, thank you.

cheers.

 

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poster:yxibow thread:590867
URL: http://www.dr-bob.org/babble/20051211/msgs/590905.html