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Re: Plan for tomorrow.... » ed_uk

Posted by zeugma on November 26, 2005, at 17:17:09

In reply to Re: Plan for tomorrow.... » zeugma, posted by ed_uk on November 26, 2005, at 16:38:48

> Hi Z
>
> I took 1200mg this evening. I don't think it did anything!
>
> Ed

hi there Ed

hmmm. I noticed a definite effect on my cognitive processes at 50 mg of modafinil. I have no idea how much adrafinil is converted to modafinil in vivo vs. inactive metabolites. I experienced insomnia from 50-100 mg, necessitating a slow titration.

Subjects in a clinical test of a single dose of 200 mg modafinil reported a subjective increase in 'excitement.' These were subjects with adult ADHD.

I wonder how much of the difference is one between adrafinil and its not-well-known metabolism (unlike amitriptyline for example, much of adrafinil is quickly converted to inactive metabolites) and also between whatever susceptibilty you might have to the drug's effects. Saying, for instance, that a drug is a 'stimulant' is only to say that it is clinically effective in keeping about 70 percent of narcolepsy patients awake. (AD response rates also are in the 60-70 percent range.)

One investigator claims that 300 mg modafinil = 20 mg d-amphetamine in terms of wakefulness promotion. I tend to agree with this, in that it is generally accepted that methylphenidate 20 mg = 10 mg d-amphetamine, roughly, and 300 mg modafinil is somewhere between 30 mg MPH (or 15 mg d-AMPH) and 60 mg MPH in terms of duration of wakefulness induction for me.

-z


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