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Tofisopam (Grandaxin) - a Hungarian benzo

Posted by ed_uk on November 14, 2005, at 13:39:26

In reply to Do you think more benzo's will come on the market?, posted by rjlockhart on November 13, 2005, at 15:57:52

Hi everyone,

Tofisopam (Grandaxin), a 2,3-benzodiazepine, is very different to the familiar 1,4-benzodiazepines eg. Klonopin, Ativan, Valium etc. Tofisopam was invented in Hungary.

Tofisopam isn't marketed in the US, it's supposedly quite a popular anti-anxiety drug in Hungary though. Darkhorse tried it, I think he liked it.

R-tofisopam, the R-isomer of tofisopam, is currently being studied as a treatment for anxiety. It might be available in the US at some point in the future.

Tofisopam does not bind to the same receptors as 1,4-benzodiazepines such as Klonopin.

Acta Pharm Hung. 1993 Mar;63(2):91-8.

Excerpts from the clinical-pharmacologic and clinical studies of Grandaxin

Szego J, Somogyi M, Papp E.

EGIS Gyogyszergyar Rt., Budapest.

The authors give a selection from the clinical-pharmacological and clinical studies of Grandaxin (tofizopam), an original Hungarian compound registered in 1976. Tofizopam, a 2,3-benzodiazepine derivative, differs from "classical" 1,4-benzodiazepines not only in chemical structure, but also in pharmacological and clinical-pharmacological properties. It is an anxiolytic without sedative-hypnotic, muscle relaxant and anticonvulsive effects. Tofizopam does not impair psychomotor and intellectual performance, like other benzodiazepines do, in the contrary, it has a mild stimulatory activity. It is potent in alleviating vegetative symptoms accompanying anxiety disorders. Tofizopam has a very low toxicity, mild side effects. The administration of tofizopam does not lead to physical or psychic dependence.

Ed


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