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Re: Lexapro: 10mg vs 20mg. Any more beneficial?? ed_uk

Posted by zeugma on November 13, 2005, at 12:06:25

In reply to Re: Lexapro: 10mg vs 20mg. Any more beneficial?? zeugma, posted by ed_uk on November 13, 2005, at 10:38:36

Hi Ed
> >I think DP/DR is somewhere in that vague spectrum of 'negative symptoms' which are common (more or less) to schizophrenia and severe depression, and which are known to be (in the case of schizophrenia) responsive to stimulants but at the cost of exacerbating positive symptoms.
> How did perphenazine affect your DP/DR? Did it make it worse? I wonder what a dopamine agonist would do..... (unfortunately, dopamine agonists sometimes cause 'sleep attacks' - notably ropinirole and pramipexole)

It's very hard to say how perphenazine affected DP/DR. First, the dose of perphenazine was way too high -mean dose around 32 mg, with 48 mg reached at one point. At these doses it caused incredible fatigue. However, I think perphenazine had an anxiolytic effect that lessened the manifestations. It didm't affect the core symptom of feeling detached from my body. I do remember perphenazine being anxiolytic- until it made me so sleepy that anxiolysis was beside the point. FWIW, I tolerated perphenazine better than molindone, spoken highly of by some here. That's not to say I cared for either. I also required a lot of Cogentin to manage the EPS, which set in immediately. perphenazine did have one favorable property- it was antipanic by lessening sensations of nausea, which tended to trigger panic attacks reliably.(That is why I had panic attacks when taking SSRI's.)

> >Unfortunately, my insurance will only cover 200 mg, so that experiment has come to an end.
> We have generic modafinil in the UK now, 100mg and 200mg tablets. Do you have the generic in the US yet? It might be a lot cheaper.

I don't think modafinil is available in the U.S. as generic yet. From what I have heard Cephalon has it on patent in the U.S. until next year (very convenient since Sparlon is coming out). .

> >I think my best hope os when Sparlon comes out early next year. It's just Provigil but in higher doses.
> What strengths of tablet will Sparlon come as?

It will come at a starting dose of 85 mg, with target doses of 340 and 425 mg. (Can't remember the intermediate dosages offhand.)From my experience, 340 mg would be about right.

BTW, I took 30 mg Ritalin instead of Provigil today. Less DP :-)

> Kind regards
> Ed




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