Posted by tecknohed on November 8, 2005, at 22:57:19
In reply to Re: The other Nardil » tecknohed, posted by Iansf on November 1, 2005, at 23:55:36
Hi Iansf
Sorry this is a late reply. I missed the fact you were asking me.
> Would using it as a suppository also avoid the tyramine issue, or would there still be a danger? And would you need to use less?
I do know that when you take MDMA (and probably many drugs) as a suppository, it definitely gives a stronger effect, maybe even double. (how do I know? Use your imaginations ;-) So it would be wise to start low.
Whether it would avoid an interaction depends on whether or not MAO is found in the rectum and if it is, does tyramine reach it in an absorbable state and not broken down/unabsorbable by then. I also dont know whether Nardil is absorbable through the rectum though I imagine it is.
Here's what happens when you eat sufficiant tyramine with MAOIs:
"Monoamine oxidase is found in the gastrointestinal tract and inactivates tyramine; when drugs prevent the catabolism of exogenous tyramine, this amino acid is absorbed and displaces norepinephrine from sympathetic nerve ending and epinephrine from the adrenal glands. If a sufficient amount of pressor amines are released, a hypertensive crisis may ensue."
teck
poster:tecknohed
thread:574256
URL: http://www.dr-bob.org/babble/20051106/msgs/576955.html