Posted by neo on October 27, 2005, at 11:44:25
In reply to Re: Any remedy for DA Receptors Tolerance?, posted by med_empowered on October 27, 2005, at 7:57:15
Hi, Thanks Lunesta and Med_E for your interesting share.
In order to understand why Amisulpride works great for me for the first 2 days and than stop completely, I have found out, in a Solian (amisulpride)Product Monography, this abstract:
"This problem [Tolerance] is even more pronounced when changes in presynaptic DA release are taken into account. The onset of narcoleptic treatment activates negative feedback systems to produce a substantial increase in DA turnover. During chronic treatment, DA turnover in the accumbens does decrease from this elevated baseline, but the tolerance is only partial, and falls far short of reversing into an absolute decrease relative to the untreated state. (Galloway & Roth 1983 and Bowers 1985)."
So i have formulated my personal Hypotesys on this problem:
- The very first days Neuroleptic DA agonist (as amis and others) increase actually the Dopamine level, blocking non-sentivized pre-synaptic receptors.
- After few days receptors develope tolerance and the level of Dopamine greatly decrease but not down to baseline. Receptors are now sentivized.
- In few weeks the plus amount of dopamine begins to work and is acquired by the cells.It is ONLY my hypotesys. Do you think i am completely wronging?
That could explain why Neuroleptic (as DA agonist) works at the begin and than you must continue for several weeks to feel the positive effects.
Could anyone support or discuss my opinion?
Thanks in advance and excuse my incorrect English.
Neo
poster:neo
thread:572106
URL: http://www.dr-bob.org/babble/20051024/msgs/572386.html