Psycho-Babble Medication | about biological treatments | Framed
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Re: Use of opiates in treating depression

Posted by SLS on October 25, 2005, at 18:03:56

In reply to Re: Use of opiates in treating depression, posted by Chairman_MAO on October 25, 2005, at 17:41:28


> If your doctor deems "opioid therapy" appropriate, there will be no reason for him to Rx you anything with an NSAID in it; they just add toxicity. There's really no reason for him to start with anything less than OxyContin.

I agree...

> That said, I recommend buprenorphine as the first-line opioid for depression. Far milder withdrawal than full agonists, vastly increased safety in overdose, and a unique receptor binding profile (kappa antagonism, conferring antipsychotic/antimanic activity possibly) make it ideal for depression. Many people prefer buprenorphine to traditional opioids for depression because it tends to be more activating as well.

I agree...

> It's also superb for anxiety; I believe it should be prescribed in lieu of benzodiazepines in many circumstances (hell, its withdrawal syndrome is a lot easier to deal with and never life-threatening!).

I gotta think about this one for awhile. The nice thing about buprenorphine is that it is self-limiting with regard to any possible euphoriant effects.

- Scott




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